A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population

We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case–control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neuroimmunology 2003-10, Vol.143 (1), p.97-100
Hauptverfasser:	Liguori, Maria, Sawcer, Stephen, Setakis, Efrosini, Compston, Alastair, Giordano, Mara, D'Alfonso, Sandra, Mellai, Marta, Malferrari, Giulia, Trojano, Maria, Livrea, Paolo, De Robertis, Francesca, Massacesi, Luca, Repice, Anna, Ballerini, Clara, Biagioli, Tiziana, Bomprezzi, Roberto, Cannoni, Stefania, Ristori, Giovanni, Salvetti, Marco, Grimaldi, Luigi M.E., Biunno, Ida, Comi, Giancarlo, Leone, Maurizio, Ferro, Isabella, Naldi, Paola, Milanese, Clara, Gellera, Cinzia, Loredana, La Mantia, Savettieri, Giovanni, Salemi, Giuseppe, Aridon, Paolo, Caputo, Domenico, Rosa Guerini, Franca, Ferrante, Pasquale, Momigliano-Richiardi, Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Case-Control Studies Continental Population Groups - genetics DNA pools Female Gene Frequency Genetic Predisposition to Disease Genetic Testing - methods Genetic Testing - statistics & numerical data Genome, Human Genotype Humans International Cooperation Italy - epidemiology Linkage Disequilibrium - genetics Male Microsatellite Repeats Microsatellites Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - genetics Whole genome linkage disequilibrium
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case–control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association.
ISSN:	0165-5728 1872-8421
DOI:	10.1016/j.jneuroim.2003.08.020