A whole genome screen for association in Polish multiple sclerosis patients

We have performed the first systematic search for MS susceptibility genes completed in the Polish population. This screen was performed using 6000 microsatellite markers typed in pooled DNA from cases ( n=200), controls ( n=200) and trio families ( n=129). Five associated markers are identified, one...

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Veröffentlicht in:	Journal of neuroimmunology 2003-10, Vol.143 (1), p.107-111
Hauptverfasser:	Bielecki, Bartosz, Mycko, Marcin P., Tronczyńska, Ewa, Bieniek, Marek, Sawcer, Stephen, Setakis, Efrosini, Benediktsson, Kjartan, Compston, Alastair, Selmaj, Krzysztof W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case-Control Studies DNA - blood Electrophoresis, Capillary Female Genetic Predisposition to Disease Genetic Testing - methods Genetic Testing - statistics & numerical data Genome, Human Genotype Humans Linkage disequilibrium Linkage Disequilibrium - genetics Male Microsatellite Repeats Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - genetics Poland - epidemiology Polymerase Chain Reaction - statistics & numerical data
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Zusammenfassung:	We have performed the first systematic search for MS susceptibility genes completed in the Polish population. This screen was performed using 6000 microsatellite markers typed in pooled DNA from cases ( n=200), controls ( n=200) and trio families ( n=129). Five associated markers are identified, one (D6S2444) from the HLA region and four are from novel regions not previously associated with MS, 2p16 (D2S2153), 3p13 (D3S3568), 7p22 (D7S2521) and 15q26 (D15S649).
ISSN:	0165-5728 1872-8421
DOI:	10.1016/j.jneuroim.2003.08.022