A metabolic basis for Alzheimer disease

Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that...

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Veröffentlicht in:	Neurochemical research 2003-10, Vol.28 (10), p.1549-1552
Hauptverfasser:	PERRY, George, NUNOMURA, Akihiko, PETOT, Grace J, SMITH, Mark A, RAINA, Arun K, ALIEV, Gjumrakch, SIEDLAK, Sandra L, HARRIS, Peggy L. R, CASADESUS, Gemma, PETERSEN, Robert B, BLIGH-GLOVER, William, BALRAJ, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Animals Biological and medical sciences Carbohydrate Metabolism Cell Size Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diet Fundamental and applied biological sciences. Psychology Humans Medical sciences Neurology Neurons - pathology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD.
ISSN:	0364-3190 1573-6903
DOI:	10.1023/A:1025678510480