Effect of nicotine on the expression of leptin and forebrain leptin receptors in the rat

We have previously reported that chronic nicotine administration (4.0 mg/kg/day by i.p. injection over 14 days) up-regulates orexin/hypocretin and neuropeptide Y (NPY) mRNA expression and peptide levels within the hypothalamus. Since there exists a coregulation between these neuropeptides and the pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2003-11, Vol.991 (1), p.222-231
Hauptverfasser:	Li, Ming D., Kane, Justin K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - chemistry Animals Biological and medical sciences Body Weight - physiology Down-Regulation Feeding Behavior - physiology Ganglionic Stimulants - pharmacology Hypothalamus Leptin Leptin - analysis Leptin - biosynthesis Male Medical sciences Nicotine Nicotine - pharmacology Prosencephalon - drug effects Prosencephalon - metabolism Rats Rats, Sprague-Dawley Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Leptin Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Time Factors Tobacco, tobacco smoking Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We have previously reported that chronic nicotine administration (4.0 mg/kg/day by i.p. injection over 14 days) up-regulates orexin/hypocretin and neuropeptide Y (NPY) mRNA expression and peptide levels within the hypothalamus. Since there exists a coregulation between these neuropeptides and the protein leptin, the present study was undertaken to determine whether nicotine has a regulatory effect on leptin signaling. Under the same experimental regimen used previously, we found that nicotine down-regulates plasma leptin concentration by 48.8% ( P
ISSN:	0006-8993 1872-6240
DOI:	10.1016/j.brainres.2003.08.024