Non-MHC Driven Exacerbation of Experimental Thyroiditis in the Postpartum Period

Non-MHC Driven Exacerbation of Experimental Thyroiditis in the Postpartum Period

Many human autoimmune diseases, including those of the thyroid gland, are affected by immune changes during pregnancy and the postpartum period. To investigate this influence, we have developed an animal model of pregnancy thyroiditis by using thyroglobulin (Tg)-induced experimental autoimmune thyro...

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Veröffentlicht in:Autoimmunity (Chur, Switzerland) Switzerland), 2001, Vol.34 (2), p.95-105
Hauptverfasser: Imaizumi, M., Pritsker, A., Kita, M., Ahmad, L., Unger, P., Davies, T. F.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Disease Models, Animal
EAT
Endocrinopathies
Experimental and animal immunopathology. Animal models
Female
Immunoglobulin G - immunology
Immunohistochemistry
Immunopathology
Interferon-gamma - metabolism
Interleukin-4 - metabolism
Lymphocytes - immunology
Major Histocompatibility Complex - immunology
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Postpartum Period - immunology
postpartum thyroiditis
Pregnancy
Spleen - metabolism
Thl/Th2
Thyroid. Thyroid axis (diseases)
Thyroiditis, Autoimmune - immunology
Thyroiditis, Autoimmune - pathology
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Zusammenfassung:Many human autoimmune diseases, including those of the thyroid gland, are affected by immune changes during pregnancy and the postpartum period. To investigate this influence, we have developed an animal model of pregnancy thyroiditis by using thyroglobulin (Tg)-induced experimental autoimmune thyroiditis (EAT). We now report a study of the postpartum period in mice with EAT. At 5 weeks postpartum, which was 9 weeks after the completion of a Tg immunization regime, the mean thyroiditis grade was significantly increased in the postpartum group from 0.23 to 0.43 (p
ISSN:0891-6934
1607-842X
DOI:10.3109/08916930109001957