Islet Amyloid and Type 2 Diabetes Mellitus
Almost a century ago, in 1901, Eugene L. Opie described “hyaline degeneration of the islands of Langerhans” in the pancreas of patients with hyperglycemia (Figure 1). 1 A relation with diabetes mellitus was suggested, although at that time insulin had not yet been identified as an islet protein. The...
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Veröffentlicht in: | The New England journal of medicine 2000-08, Vol.343 (6), p.411-419 |
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Sprache: | eng |
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Zusammenfassung: | Almost a century ago, in 1901, Eugene L. Opie described “hyaline degeneration of the islands of Langerhans” in the pancreas of patients with hyperglycemia (Figure 1).
1
A relation with diabetes mellitus was suggested, although at that time insulin had not yet been identified as an islet protein. The chief component of the proteinaceous deposits described by Opie — later referred to as islet amyloid — was identified in 1986 as a protein of beta-cell origin named islet amyloid polypeptide.
2
Islet amyloid is a characteristic pathological finding in patients with type 2 diabetes mellitus, being present in more than 90 percent. . . . |
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ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJM200008103430607 |