Islet Amyloid and Type 2 Diabetes Mellitus

Almost a century ago, in 1901, Eugene L. Opie described “hyaline degeneration of the islands of Langerhans” in the pancreas of patients with hyperglycemia (Figure 1). 1 A relation with diabetes mellitus was suggested, although at that time insulin had not yet been identified as an islet protein. The...

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Veröffentlicht in:The New England journal of medicine 2000-08, Vol.343 (6), p.411-419
Hauptverfasser: Höppener, Jo W.M, Ahrén, Bo, Lips, Cornelis J.M
Format: Artikel
Sprache:eng
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Zusammenfassung:Almost a century ago, in 1901, Eugene L. Opie described “hyaline degeneration of the islands of Langerhans” in the pancreas of patients with hyperglycemia (Figure 1). 1 A relation with diabetes mellitus was suggested, although at that time insulin had not yet been identified as an islet protein. The chief component of the proteinaceous deposits described by Opie — later referred to as islet amyloid — was identified in 1986 as a protein of beta-cell origin named islet amyloid polypeptide. 2 Islet amyloid is a characteristic pathological finding in patients with type 2 diabetes mellitus, being present in more than 90 percent. . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM200008103430607