Isoniazid pharmacokinetics in children according to acetylator phenotype

Isoniazid pharmacokinetics in children according to acetylator phenotype

The pharmacokinetics of isoniazid (INH) was studied in children (0–196 months old) according to their acetylator phenotype, estimated from the metabolic acetyl INH/INH molar plasma concentration ratio (MR) measured 3 h after INH oral administration. There were 17 slow (MR 

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Veröffentlicht in:Fundamental & clinical pharmacology 2001-10, Vol.15 (5), p.355-359
Hauptverfasser: Rey, Elisabeth, Gendrel, Dominique, Treluyer, Jean Marc, Tran, Agnès, Pariente-Khayat, Ann, D'Athis, Philippe, Pons, Gérard
Format: Artikel
Sprache:eng
Schlagworte:
Acetylation
acetylator phenotype
Adolescent
Age Factors
Child
Child, Preschool
children
Half-Life
Humans
Infant
Infant, Newborn
Isoniazid
Isoniazid - blood
Isoniazid - pharmacokinetics
Metabolic Clearance Rate
pharmacokinetics
Phenotype
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Zusammenfassung:The pharmacokinetics of isoniazid (INH) was studied in children (0–196 months old) according to their acetylator phenotype, estimated from the metabolic acetyl INH/INH molar plasma concentration ratio (MR) measured 3 h after INH oral administration. There were 17 slow (MR 
ISSN:0767-3981
1472-8206
DOI:10.1046/j.1472-8206.2001.00044.x