Age-related differences in MAP kinase activity in VSMC in response to glucose or TNF-α

Aortic vascular smooth muscle cells (VSMC) were used to study the effect of age on responses to high glucose concentrations or the cytokine, tumor necrosis factor‐alpha (TNF‐α). Activator protein‐1 (AP‐1) binding to DNA increased more in VSMC from old versus young rats (P

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Veröffentlicht in:	Journal of cellular physiology 2003-12, Vol.197 (3), p.418-425
Hauptverfasser:	Li, Muyao, Mossman, Brooke T., Kolpa, Emily, Timblin, Cynthia R., Shukla, Arti, Taatjes, Douglas J., Fukagawa, Naomi K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Arteriosclerosis - enzymology Arteriosclerosis - etiology Arteriosclerosis - physiopathology Cell Division - drug effects Cell Division - physiology Cells, Cultured Diabetes Complications DNA - metabolism Enzyme Inhibitors - pharmacology Glucose - metabolism Glucose - pharmacology JNK Mitogen-Activated Protein Kinases Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - enzymology p38 Mitogen-Activated Protein Kinases Proliferating Cell Nuclear Antigen - drug effects Proliferating Cell Nuclear Antigen - metabolism Rats Rats, Inbred F344 Risk Factors Transcription Factor AP-1 - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology
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Beschreibung
Zusammenfassung:	Aortic vascular smooth muscle cells (VSMC) were used to study the effect of age on responses to high glucose concentrations or the cytokine, tumor necrosis factor‐alpha (TNF‐α). Activator protein‐1 (AP‐1) binding to DNA increased more in VSMC from old versus young rats (P
ISSN:	0021-9541 1097-4652
DOI:	10.1002/jcp.10384