Clethramycin, a New Inhibitor of Pollen Tube Growth with Antifungal Activity from Streptomyces hygroscopicus TP-A0623: II. Physico-chemical Properties and Structure Determination
Clethramycin is a novel linear polyene polyketide produced by a plant-associated actinomycete Streptomyces hygroscopicus TP-A0623. It possesses a guanidino and carboxyl residue at each end and an O-sulfate group and a hexaene moiety in the molecule, and its molecular formula is C63H99N3O18S. The str...
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| Veröffentlicht in: | Journal of antibiotics 2003/08/25, Vol.56(8), pp.705-708 |
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| container_title | Journal of antibiotics |
| container_volume | 56 |
| creator | IGARASHI, YASUHIRO IWASHITA, TAKASHI FUJITA, TSUYOSHI NAOKI, HIDEO YAMAKAWA, TAKASHI YOSHIDA, RYUJI FURUMAI, TAMOTSU |
| description | Clethramycin is a novel linear polyene polyketide produced by a plant-associated actinomycete Streptomyces hygroscopicus TP-A0623. It possesses a guanidino and carboxyl residue at each end and an O-sulfate group and a hexaene moiety in the molecule, and its molecular formula is C63H99N3O18S. The structure was determined by analyzing 2D-NMR and FAB-MS data, using 13C-enriched compounds. Clethramycin is structurally similar to linearmycin, an inhibitor of spheroplast regeneration in Candida albicans. Clethramycin shows potent antifungal and pollen tube growth inhibitory activity. |
| doi_str_mv | 10.7164/antibiotics.56.705 |
| format | Article |
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Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Fatty Acids, Unsaturated - chemistry</subject><subject>Fatty Acids, Unsaturated - pharmacology</subject><subject>Flowers - drug effects</subject><subject>Flowers - growth & development</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Sulfuric Acid Esters - chemistry</topic><topic>Sulfuric Acid Esters - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IGARASHI, YASUHIRO</creatorcontrib><creatorcontrib>IWASHITA, TAKASHI</creatorcontrib><creatorcontrib>FUJITA, TSUYOSHI</creatorcontrib><creatorcontrib>NAOKI, HIDEO</creatorcontrib><creatorcontrib>YAMAKAWA, TAKASHI</creatorcontrib><creatorcontrib>YOSHIDA, RYUJI</creatorcontrib><creatorcontrib>FURUMAI, TAMOTSU</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IGARASHI, YASUHIRO</au><au>IWASHITA, TAKASHI</au><au>FUJITA, TSUYOSHI</au><au>NAOKI, HIDEO</au><au>YAMAKAWA, TAKASHI</au><au>YOSHIDA, RYUJI</au><au>FURUMAI, TAMOTSU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clethramycin, a New Inhibitor of Pollen Tube Growth with Antifungal Activity from Streptomyces hygroscopicus TP-A0623: II. Physico-chemical Properties and Structure Determination</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>56</volume><issue>8</issue><spage>705</spage><epage>708</epage><pages>705-708</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Clethramycin is a novel linear polyene polyketide produced by a plant-associated actinomycete Streptomyces hygroscopicus TP-A0623. It possesses a guanidino and carboxyl residue at each end and an O-sulfate group and a hexaene moiety in the molecule, and its molecular formula is C63H99N3O18S. The structure was determined by analyzing 2D-NMR and FAB-MS data, using 13C-enriched compounds. Clethramycin is structurally similar to linearmycin, an inhibitor of spheroplast regeneration in Candida albicans. 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| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemistry Antifungal Agents - pharmacology Biological and medical sciences Fatty Acids, Unsaturated - chemistry Fatty Acids, Unsaturated - pharmacology Flowers - drug effects Flowers - growth & development Medical sciences Pharmacology. Drug treatments Sulfuric Acid Esters - chemistry Sulfuric Acid Esters - pharmacology |
| title | Clethramycin, a New Inhibitor of Pollen Tube Growth with Antifungal Activity from Streptomyces hygroscopicus TP-A0623: II. Physico-chemical Properties and Structure Determination |
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