Clethramycin, a New Inhibitor of Pollen Tube Growth with Antifungal Activity from Streptomyces hygroscopicus TP-A0623: II. Physico-chemical Properties and Structure Determination

Clethramycin is a novel linear polyene polyketide produced by a plant-associated actinomycete Streptomyces hygroscopicus TP-A0623. It possesses a guanidino and carboxyl residue at each end and an O-sulfate group and a hexaene moiety in the molecule, and its molecular formula is C63H99N3O18S. The str...

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Veröffentlicht in:	Journal of antibiotics 2003/08/25, Vol.56(8), pp.705-708
Hauptverfasser:	IGARASHI, YASUHIRO, IWASHITA, TAKASHI, FUJITA, TSUYOSHI, NAOKI, HIDEO, YAMAKAWA, TAKASHI, YOSHIDA, RYUJI, FURUMAI, TAMOTSU
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemistry Antifungal Agents - pharmacology Biological and medical sciences Fatty Acids, Unsaturated - chemistry Fatty Acids, Unsaturated - pharmacology Flowers - drug effects Flowers - growth & development Medical sciences Pharmacology. Drug treatments Sulfuric Acid Esters - chemistry Sulfuric Acid Esters - pharmacology
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Zusammenfassung:	Clethramycin is a novel linear polyene polyketide produced by a plant-associated actinomycete Streptomyces hygroscopicus TP-A0623. It possesses a guanidino and carboxyl residue at each end and an O-sulfate group and a hexaene moiety in the molecule, and its molecular formula is C63H99N3O18S. The structure was determined by analyzing 2D-NMR and FAB-MS data, using 13C-enriched compounds. Clethramycin is structurally similar to linearmycin, an inhibitor of spheroplast regeneration in Candida albicans. Clethramycin shows potent antifungal and pollen tube growth inhibitory activity.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.56.705