Facilitation and disruption of memory for the passive avoidance task in the day-old chick using dopamine D1 receptor compounds

This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training...

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Veröffentlicht in:	Behavioural pharmacology 2003-11, Vol.14 (7), p.525-532
Hauptverfasser:	Hale, M. W, Crowe, S. F
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology Age Factors Animals Appetitive Behavior - drug effects Association Learning - drug effects Avoidance Learning - drug effects Benzazepines - pharmacology Brain - drug effects Chickens Discrimination Learning - drug effects Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Dose-Response Relationship, Drug Injections, Subcutaneous Memory, Short-Term - drug effects Mental Recall - drug effects Quinpirole - pharmacology Receptors, Dopamine D1 - drug effects Receptors, Dopamine D2 - drug effects Retention (Psychology) - drug effects Sulpiride - pharmacology Taste - drug effects
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Beschreibung
Zusammenfassung:	This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training with a strong (100% methyl anthranilate) aversant experience. The D1 agonist, SKF38393, was found to facilitate memory in chicks given a weak (20% vol/vol methyl anthranilate) training experience. The D2 antagonist, sulpiride, and the D2 agonist, quinpirole, showed no memory effects. The research indicates an important role for dopamine D1-dependent mechanisms in memory formation in the chick.
ISSN:	0955-8810 1473-5849
DOI:	10.1097/00008877-200311000-00005