GC-MS Quantitation of Fragrance Compounds Suspected To Cause Skin Reactions. 1

Recent changes in European legislation require monitoring of 24 volatile compounds in perfumes as they might elicit skin sensitization. This paper reports a GC-MS quantitation procedure for their determination in fragrance concentrates. GC and MS conditions were optimized for a routine use: analysi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of agricultural and food chemistry 2003-10, Vol.51 (22), p.6398-6403
Hauptverfasser:	Chaintreau, Alain, Joulain, Daniel, Marin, Christophe, Schmidt, Claus-Oliver, Vey, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - analysis Antigens, allergens Applied sciences Biological and medical sciences Chemical industry and chemicals Dermatitis, Contact - etiology Essential oils, perfumes Exact sciences and technology Fundamental and applied biological sciences. Psychology Fundamental immunology Gas Chromatography-Mass Spectrometry Immediate hypersensitivity. Allergy. Anaphylaxis, etc Immunobiology Perfume - chemistry Quality Control Solvents Volatilization Washing products. Cosmetics and toiletries. Perfumes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Recent changes in European legislation require monitoring of 24 volatile compounds in perfumes as they might elicit skin sensitization. This paper reports a GC-MS quantitation procedure for their determination in fragrance concentrates. GC and MS conditions were optimized for a routine use: analysis within 30 min, solvent and internal standard selection, and stock solution stability. Calibration curves were linear in the range of 2−100 mg/L with coefficients of determination in excess of 0.99. The method was tested using real perfumes spiked with known amounts of reference compounds. Keywords: Allergen; GC-MS; quantitation; skin reaction; fragrances; perfumes
ISSN:	0021-8561 1520-5118
DOI:	10.1021/jf030363t