Increased Liver Decompensation Risk with Atypical Hepatitis C Virus Antibody Levels

Knowledge of serum markers of liver decompensation would facilitate care of patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections. HCV load and anti-c33c and anti-NS5 levels did not distinguish 28 HCV- and HIV-positive predecompensation patients from 28 matched cont...

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Veröffentlicht in:	The Journal of infectious diseases 2000-08, Vol.182 (2), p.590-594
Hauptverfasser:	Goedert, James J., Hatzakis, Angelos, Maloney, Elizabeth M., Eyster, M. Elaine
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibodies Antigens Biological and medical sciences Case-Control Studies Cohort Studies Concise Comunications Hemophilia Hemophilia A - complications Hepacivirus Hepacivirus - isolation & purification Hepatitis C - blood Hepatitis C - complications Hepatitis C Antibodies - blood Hepatitis C virus HIV HIV Infections - complications Human immunodeficiency virus Human viral diseases Humans Infections Infectious diseases Liver Liver diseases Liver Failure - complications Medical sciences Reactivity Viral diseases Viral hepatitis Viral Load Viruses
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Zusammenfassung:	Knowledge of serum markers of liver decompensation would facilitate care of patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections. HCV load and anti-c33c and anti-NS5 levels did not distinguish 28 HCV- and HIV-positive predecompensation patients from 28 matched control patients, whereas more patients than controls had high anti-c100(p) and low anti-c22(p). In multivariate analysis, decompensation was associated with high anti-c100(p) titer (⩾1:4050; odds ratio [OR], 3.4; 95% confidence interval [CI], 1.1–11.5) and low anti-c22(p) (
ISSN:	0022-1899 1537-6613
DOI:	10.1086/315712