Salt intake and non-ACE pathways for intrarenal angiotensin II generation in man
Angiotensin-converting enzyme (ACE) plays a crucial role in the generation of angiotensin II (Ang II) via conversion from angiotensin I (Ang I). There has been substantial recent interest in non-ACE pathways of Ang II generation in the heart, large arteries, and the kidney. In the case of the human...
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Veröffentlicht in: | Journal of the renin-angiotensin-aldosterone system 2001-03, Vol.2 (1), p.14-18 |
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Sprache: | eng |
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Zusammenfassung: | Angiotensin-converting enzyme (ACE) plays a crucial role in the generation of angiotensin II (Ang II) via conversion from angiotensin I (Ang I). There has been substantial recent interest in non-ACE pathways of Ang II generation in the heart, large arteries, and the kidney. In the case of the human kidney, studied when in balance on a low-salt diet, the renal haemodynamic response to Ang II antagonists substantially exceeds the renal response to ACE inhibitors (ACE-I), suggesting that about 30—40% of Ang II-generation occurs via non-ACE pathways. In this study, we examined the relative contribution of non-ACE pathways, by comparing the response to candesartan and to captopril at the top of the dose-response in normal humans when in balance on a low-salt, as well as a high-salt, diet. As anticipated on a low-salt diet, the increase in renal plasma flow (RPF) in response to candesartan (165±14 mL/min/1.73m 2) significantly exceeded the response to captopril (118±12 mL/min/1.73m 2; p |
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ISSN: | 1470-3203 1752-8976 |
DOI: | 10.3317/jraas.2001.002 |