Synthesis and biological activities of an α-methyl and a β-methyl carbapenem and the corresponding unsubstituted compound

The carbapenem potassium salts 4, 7 and 8 were prepared. Their rates of β-lactam hydrolysis and their biological activities, particularly their β-lactamase inhibiting properties, were examined and explained on the basis of their different substitution and pyramidality.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-06, Vol.10 (12), p.1389-1391
Hauptverfasser:	Pfaendler, Hans Rudolf, Weishaupt, Ralf, Meffert, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Carbapenems - chemical synthesis Carbapenems - chemistry Carbapenems - pharmacology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	The carbapenem potassium salts 4, 7 and 8 were prepared. Their rates of β-lactam hydrolysis and their biological activities, particularly their β-lactamase inhibiting properties, were examined and explained on the basis of their different substitution and pyramidality.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00248-1