Male infertility: recent advances and a look towards the future

The past decade has witnessed clinical and basic scientific advances that have revolutionized the diagnosis and treatment of the infertile male. Advances in the clinic and laboratory have resulted in men who were previously thought to be hopelessly infertile, but who are now able to conceive their own biologic offspring. In the future, we believe that the laboratory will continue to play a key role in advancing our ability both to diagnose and to treat the infertile male. We summarize here some of the major advances of the past decade that have influenced our treatment and our understanding of the etiology of male infertility. When possible, clinical innovations and advances in basic science are discussed in combination in order to emphasize the translational importance of reproductive research.