Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin

Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT). TGB add-on therapy showed no significant weight changes when added to either PHT or CBZ. CBZ add-on therapy showed a significant perce...

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Veröffentlicht in:	Epilepsy research 2000-08, Vol.41 (1), p.23-28
Hauptverfasser:	Hogan, Robert E, Bertrand, Mary E, Deaton, Roger L, Sommerville, Kenneth W
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - therapeutic use Antiepileptic drugs Biological and medical sciences Body Weight - drug effects Carbamazepine Carbamazepine - therapeutic use Double-Blind Method Drug Therapy, Combination Drug toxicity and drugs side effects treatment Epilepsy Epilepsy - drug therapy Epilepsy - physiopathology Humans Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Nipecotic Acids - therapeutic use Pharmacology. Drug treatments Phenytoin - therapeutic use Tiagabine Total body weight Weight Gain
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Zusammenfassung:	Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT). TGB add-on therapy showed no significant weight changes when added to either PHT or CBZ. CBZ add-on therapy showed a significant percentage weight gain of a mean body increase of 1.5% ( P=0.002). Adjunctive TGB therapy had no significant effect on total body weight, while adjunctive CBZ therapy was associated with weight gain.
ISSN:	0920-1211 1872-6844
DOI:	10.1016/S0920-1211(00)00125-X