Increased tubuloglomerular feedback reactivity is associated with increased NO production in the streptozotocin-diabetic rat

The characteristics of the tubuloglomerular feedback (TGF) mechanism were examined in streptozotocin-diabetic rats. This model is known to induce damage in the distal tubular system and thus Tamm–Horsfall protein (THP) secretion. Three groups of male Sprague–Dawley rats were studied: (A) diabetic ra...

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Veröffentlicht in:	Journal of diabetes and its complications 2000, Vol.14 (1), p.46-52
Hauptverfasser:	Thorup, Christian, Ollerstam, Anna, Persson, A.Erik G, Torffvit, Ole
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Associated diseases and complications Biological and medical sciences Blood Pressure Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Inhibitors - pharmacology Feedback Glomerular Filtration Rate Kidney Glomerulus - physiopathology Kidney Tubules - physiopathology Male Medical sciences NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors NO synthase Rats Rats, Sprague-Dawley Stop-flow pressure Tamm–Horsfall protein Tubuloglomerular feedback Vasoconstriction
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Zusammenfassung:	The characteristics of the tubuloglomerular feedback (TGF) mechanism were examined in streptozotocin-diabetic rats. This model is known to induce damage in the distal tubular system and thus Tamm–Horsfall protein (THP) secretion. Three groups of male Sprague–Dawley rats were studied: (A) diabetic rats with blood glucose levels (BG)
ISSN:	1056-8727 1873-460X
DOI:	10.1016/S1056-8727(00)00056-8