Insulin resistance in diabetic microangiopathies

To investigate whether insulin resistance is associated with diabetic microangiopathies in type 2 diabetes mellitus, insulin sensitivity was measured in 133 type 2 diabetic subjects with or without diabetic retinopathy and/or nephropathy. Insulin sensitivity was measured by steady-state plasma gluco...

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Veröffentlicht in:	Journal of diabetes and its complications 2000, Vol.14 (1), p.40-45
Hauptverfasser:	Suzuki, Masaaki, Kanazawa, Akio, Shiba, Mariko, Kojima, Hideto, Harano, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Associated diseases and complications Biological and medical sciences Diabetes Mellitus, Type 2 - complications Diabetes. Impaired glucose tolerance Diabetic Angiopathies - complications Diabetic microangiopathy Diabetic Nephropathies - complications Diabetic Nephropathies - epidemiology Diabetic nephropathy Diabetic retinopathy Diabetic Retinopathy - complications Diabetic Retinopathy - epidemiology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Glucose Clamp Technique Humans Insulin Resistance Medical sciences Middle Aged Proteinuria - complications
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Zusammenfassung:	To investigate whether insulin resistance is associated with diabetic microangiopathies in type 2 diabetes mellitus, insulin sensitivity was measured in 133 type 2 diabetic subjects with or without diabetic retinopathy and/or nephropathy. Insulin sensitivity was measured by steady-state plasma glucose method or euglycemic glucose clamp method. Regarding retinopathy, in the insulin-resistant group, advanced retinopathy (preproliferative and proliferative retinopathy) was more frequently observed compared with the insulin-sensitive group (significance: p
ISSN:	1056-8727 1873-460X
DOI:	10.1016/S1056-8727(00)00052-0