Tripropeptins, Novel Antimicrobial Agents Produced by Lysobacter sp: I. Taxonomy, Isolation and Biological Activities

Peptide antibiotics tripropeptins A, B, C, D and Z were isolated from cultured cells and broth of Lysobacter sp. The differences among these components are in the lengths of the alkyl side chain. Tripropeptins are active against Gram-positive bacteria including MRSA in vitro. Bactericidal activity o...

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Veröffentlicht in:	Journal of antibiotics 2001/12/25, Vol.54(12), pp.1054-1059
Hauptverfasser:	HASHIZUME, HIDEKI, IGARASHI, MASAYUKI, HATTORI, SEIKO, HORI, MAKOTO, HAMADA, MASA, TAKEUCHI, TOMIO
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Applied microbiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Medical sciences Microbial Sensitivity Tests Microbiology Pharmacology. Drug treatments Structure-Activity Relationship
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Zusammenfassung:	Peptide antibiotics tripropeptins A, B, C, D and Z were isolated from cultured cells and broth of Lysobacter sp. The differences among these components are in the lengths of the alkyl side chain. Tripropeptins are active against Gram-positive bacteria including MRSA in vitro. Bactericidal activity of tripropeptin C disappeared in the simultaneous presence of chloramphenicol, a bacteriostatic agent.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.54.1054