Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies
The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA hapl...
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| Veröffentlicht in: | Neurology 2000-07, Vol.55 (2), p.302-304 |
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| container_title | Neurology |
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| creator | CHINNERY, P. F TAYLOR, G. A HOWELL, N ANDREWS, R. M MORRIS, C. M TAYLOR, R. W MCKEITH, I. G PERRY, R. H EDWARDSON, J. A TURNBULL, D. M |
| description | The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup H was overrepresented in the DLB patients when compared with control subjects. Additional studies are needed to clarify the significance of the association. |
| doi_str_mv | 10.1212/WNL.55.2.302 |
| format | Article |
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F ; TAYLOR, G. A ; HOWELL, N ; ANDREWS, R. M ; MORRIS, C. M ; TAYLOR, R. W ; MCKEITH, I. G ; PERRY, R. H ; EDWARDSON, J. A ; TURNBULL, D. M</creator><creatorcontrib>CHINNERY, P. F ; TAYLOR, G. A ; HOWELL, N ; ANDREWS, R. M ; MORRIS, C. M ; TAYLOR, R. W ; MCKEITH, I. G ; PERRY, R. H ; EDWARDSON, J. A ; TURNBULL, D. M</creatorcontrib><description>The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup H was overrepresented in the DLB patients when compared with control subjects. Additional studies are needed to clarify the significance of the association.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.55.2.302</identifier><identifier>PMID: 10908912</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Alzheimer Disease - genetics ; Alzheimer Disease - pathology ; Apolipoproteins E - genetics ; Biological and medical sciences ; Brain - pathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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Prion diseases</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>Lewy Body Disease - genetics</subject><subject>Lewy Body Disease - pathology</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Risk</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAURi0EouWxMSMPiIkEP2LHHquWlxTKUgSb5TgONUriECeq-u8JtBJMd_iOjq4OABcYxZhgcvu2zGLGYhJTRA7AFDPCI07J-yGYIkREREUqJuAkhE-ExjGVx2CCkURCYjIFq2fXe7P2TdE5XcHFcgbXuq38R-eHNkDdFDAMwdi2d7mrXL-FvYezxe9Q2No2vdNw4_o1zOxmC3NfOBvOwFGpq2DP9_cUvN7freaPUfby8DSfZZGhTPZRbhMrMJXIIp2kBhmOEk40ylGCjclFSUmSywILynPEuOGCl9KWgknLueSGnoLrnbft_NdgQ69qN_5aVbqxfggqxYSx0TmCNzvQdD6Ezpaq7Vytu63CSP1UVGNFxZgiaqw44pd775DXtvgH77KNwNUe0MHoqux0Y1z44xKWMCboNyY7eVc</recordid><startdate>20000725</startdate><enddate>20000725</enddate><creator>CHINNERY, P. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2000-07-25</date><risdate>2000</risdate><volume>55</volume><issue>2</issue><spage>302</spage><epage>304</epage><pages>302-304</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup H was overrepresented in the DLB patients when compared with control subjects. Additional studies are needed to clarify the significance of the association.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10908912</pmid><doi>10.1212/WNL.55.2.302</doi><tpages>3</tpages></addata></record> |
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| ispartof | Neurology, 2000-07, Vol.55 (2), p.302-304 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Aged Alzheimer Disease - genetics Alzheimer Disease - pathology Apolipoproteins E - genetics Biological and medical sciences Brain - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA, Mitochondrial - genetics Genetic Predisposition to Disease - genetics Genotype Haplotypes - genetics Humans Lewy Body Disease - genetics Lewy Body Disease - pathology Medical sciences Neurology Risk |
| title | Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies |
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