Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies

The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA hapl...

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Veröffentlicht in:	Neurology 2000-07, Vol.55 (2), p.302-304
Hauptverfasser:	CHINNERY, P. F, TAYLOR, G. A, HOWELL, N, ANDREWS, R. M, MORRIS, C. M, TAYLOR, R. W, MCKEITH, I. G, PERRY, R. H, EDWARDSON, J. A, TURNBULL, D. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - genetics Alzheimer Disease - pathology Apolipoproteins E - genetics Biological and medical sciences Brain - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA, Mitochondrial - genetics Genetic Predisposition to Disease - genetics Genotype Haplotypes - genetics Humans Lewy Body Disease - genetics Lewy Body Disease - pathology Medical sciences Neurology Risk
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Zusammenfassung:	The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup H was overrepresented in the DLB patients when compared with control subjects. Additional studies are needed to clarify the significance of the association.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.55.2.302