Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues

The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chain aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series wit...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-07, Vol.10 (14), p.1519-1522
Hauptverfasser:	deLong, Mitchell A, Amburgey, Jack, Taylor, Cynthia, Wos, John A, Soper, David L, Wang, Yili, Hicks, Renee
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Humans Kinetics Medical sciences Miscellaneous Models, Structural Molecular Conformation Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Prostaglandins - chemical synthesis Prostaglandins - chemistry Prostaglandins - metabolism Receptors, Prostaglandin - metabolism Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chain aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF 2α.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00273-0