Relationship between Hypertensive Left Ventricular Hypertrophy and Levels of Endothelin and Nitric Oxide
To investigate the relationship between hypertensive left ventricular hypertrophy (LVH) and levels of endothelin (ET) and nitric oxide (NO), and to provide an experimental basis for prevention and treatment of hypertensive LVH. Fifty eight hypertensive patients and 14 healthy controls were studied....
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| Veröffentlicht in: | Hypertension Research 2000, Vol.23(4), pp.377-380 |
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| container_title | Hypertension Research |
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| creator | HUA, Liyan LI, Changyu XIA, Daozi QU, Peng LI, Zhongyan ZHANG, Weijiang FENG, Xiaohai |
| description | To investigate the relationship between hypertensive left ventricular hypertrophy (LVH) and levels of endothelin (ET) and nitric oxide (NO), and to provide an experimental basis for prevention and treatment of hypertensive LVH. Fifty eight hypertensive patients and 14 healthy controls were studied. All patients were examined by echocardiography. Left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated using Devereux RB formula. Hypertensive patients were divided into a LVH (+) group (n=21) and a LVH (-) group (n=37), and the levels of endothelin and nitric oxide in the peripheral venous blood were measured. The mean ET level was significantly higher in the LVH (+) group than in LVH (-) group (p |
| doi_str_mv | 10.1291/hypres.23.377 |
| format | Article |
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Fifty eight hypertensive patients and 14 healthy controls were studied. All patients were examined by echocardiography. Left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated using Devereux RB formula. Hypertensive patients were divided into a LVH (+) group (n=21) and a LVH (-) group (n=37), and the levels of endothelin and nitric oxide in the peripheral venous blood were measured. The mean ET level was significantly higher in the LVH (+) group than in LVH (-) group (p <0.05), but the NO level was significantly lower in the LVH (+) group. The ET/NO ratio was significantly higher in the LVH (+) group than in LVH (-) group (p<0.01). For the stepwise multiple regression analysis, the LVMI of hypertensive patients served as a dependent variable, and age, sex, BMI, MAP, ET, NO, and ET/NO served as independent variables. Only MAP, ET, and NO were found to have significant correlation to hypertensive LVH. ET had a significant positive correlation, and NO a significant negative relation to LVMI, but ET/NO showed no correlation to hypertensive LVH. ET and NO are involved in hypertensive LVH; the independent action of ET and NO in the pathogenesis of hypertensive LVH may weaken the relation between ET/NO and hypertensive LVH. 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Fifty eight hypertensive patients and 14 healthy controls were studied. All patients were examined by echocardiography. Left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated using Devereux RB formula. Hypertensive patients were divided into a LVH (+) group (n=21) and a LVH (-) group (n=37), and the levels of endothelin and nitric oxide in the peripheral venous blood were measured. The mean ET level was significantly higher in the LVH (+) group than in LVH (-) group (p <0.05), but the NO level was significantly lower in the LVH (+) group. The ET/NO ratio was significantly higher in the LVH (+) group than in LVH (-) group (p<0.01). For the stepwise multiple regression analysis, the LVMI of hypertensive patients served as a dependent variable, and age, sex, BMI, MAP, ET, NO, and ET/NO served as independent variables. Only MAP, ET, and NO were found to have significant correlation to hypertensive LVH. ET had a significant positive correlation, and NO a significant negative relation to LVMI, but ET/NO showed no correlation to hypertensive LVH. ET and NO are involved in hypertensive LVH; the independent action of ET and NO in the pathogenesis of hypertensive LVH may weaken the relation between ET/NO and hypertensive LVH. (Hypertens Res 2000; 23: 377-380)</description><subject>Adult</subject><subject>endothelin</subject><subject>Endothelins - blood</subject><subject>Female</subject><subject>Humans</subject><subject>hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - complications</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>left ventricular hypertrophy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Regression Analysis</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtv2zAURomgQeymHbsWmrrJ5UsUNRaG8wCMBiiSrARJXVYMZEol6bT-95Ejw-hCDt-5ZzgIfSF4RWhDvneHMUJaUbZidX2BloRxWXJK-Ae0xA0RZSOYWKCPKb1gTGXVkCu0INNC61osUfcLep39EFLnx8JA_gsQirvDCDFDSP4Vii24XDxDyNHbfa_jaY3D2B0KHdoJeIU-FYMrNqEdcge9D-_DT3-8KR7--RY-oUun-wSfT_81errZPK7vyu3D7f36x7a0laxzSWntsDa2xVg0hmurZSMtcC6BUwymdhyEcNS4FmhrCDUGSwmVIcKJikt2jb7N3jEOf_aQstr5ZKHvdYBhn1RNaEUZExNYzqCNQ0oRnBqj3-l4UASrY1o1p1WUqSntxH89ifdmB-1_9NxyAm5m4CVl_RvOgI7Z2x5OOtI09Kjk8zOZz4DtdFQQ2Bv-UJG0</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>HUA, Liyan</creator><creator>LI, Changyu</creator><creator>XIA, Daozi</creator><creator>QU, Peng</creator><creator>LI, Zhongyan</creator><creator>ZHANG, Weijiang</creator><creator>FENG, Xiaohai</creator><general>The Japanese Society of Hypertension</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>Relationship between Hypertensive Left Ventricular Hypertrophy and Levels of Endothelin and Nitric Oxide</title><author>HUA, Liyan ; LI, Changyu ; XIA, Daozi ; QU, Peng ; LI, Zhongyan ; ZHANG, Weijiang ; FENG, Xiaohai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-227f0abcd0069b4aca898ce448e420eb7f4e66f2bfde2db12bb088e5b16f65483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>endothelin</topic><topic>Endothelins - blood</topic><topic>Female</topic><topic>Humans</topic><topic>hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - complications</topic><topic>Hypertrophy, Left Ventricular - etiology</topic><topic>left ventricular hypertrophy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Regression Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HUA, Liyan</creatorcontrib><creatorcontrib>LI, Changyu</creatorcontrib><creatorcontrib>XIA, Daozi</creatorcontrib><creatorcontrib>QU, Peng</creatorcontrib><creatorcontrib>LI, Zhongyan</creatorcontrib><creatorcontrib>ZHANG, Weijiang</creatorcontrib><creatorcontrib>FENG, Xiaohai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HUA, Liyan</au><au>LI, Changyu</au><au>XIA, Daozi</au><au>QU, Peng</au><au>LI, Zhongyan</au><au>ZHANG, Weijiang</au><au>FENG, Xiaohai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Hypertensive Left Ventricular Hypertrophy and Levels of Endothelin and Nitric Oxide</atitle><jtitle>Hypertension Research</jtitle><addtitle>Hypertension Research</addtitle><date>2000</date><risdate>2000</risdate><volume>23</volume><issue>4</issue><spage>377</spage><epage>380</epage><pages>377-380</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>To investigate the relationship between hypertensive left ventricular hypertrophy (LVH) and levels of endothelin (ET) and nitric oxide (NO), and to provide an experimental basis for prevention and treatment of hypertensive LVH. Fifty eight hypertensive patients and 14 healthy controls were studied. All patients were examined by echocardiography. Left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated using Devereux RB formula. Hypertensive patients were divided into a LVH (+) group (n=21) and a LVH (-) group (n=37), and the levels of endothelin and nitric oxide in the peripheral venous blood were measured. The mean ET level was significantly higher in the LVH (+) group than in LVH (-) group (p <0.05), but the NO level was significantly lower in the LVH (+) group. The ET/NO ratio was significantly higher in the LVH (+) group than in LVH (-) group (p<0.01). For the stepwise multiple regression analysis, the LVMI of hypertensive patients served as a dependent variable, and age, sex, BMI, MAP, ET, NO, and ET/NO served as independent variables. Only MAP, ET, and NO were found to have significant correlation to hypertensive LVH. ET had a significant positive correlation, and NO a significant negative relation to LVMI, but ET/NO showed no correlation to hypertensive LVH. ET and NO are involved in hypertensive LVH; the independent action of ET and NO in the pathogenesis of hypertensive LVH may weaken the relation between ET/NO and hypertensive LVH. (Hypertens Res 2000; 23: 377-380)</abstract><cop>England</cop><pub>The Japanese Society of Hypertension</pub><pmid>10912776</pmid><doi>10.1291/hypres.23.377</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult endothelin Endothelins - blood Female Humans hypertension Hypertension - blood Hypertension - complications Hypertrophy, Left Ventricular - etiology left ventricular hypertrophy Male Middle Aged nitric oxide Nitric Oxide - blood Regression Analysis |
| title | Relationship between Hypertensive Left Ventricular Hypertrophy and Levels of Endothelin and Nitric Oxide |
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