Relationship between Hypertensive Left Ventricular Hypertrophy and Levels of Endothelin and Nitric Oxide

Relationship between Hypertensive Left Ventricular Hypertrophy and Levels of Endothelin and Nitric Oxide

To investigate the relationship between hypertensive left ventricular hypertrophy (LVH) and levels of endothelin (ET) and nitric oxide (NO), and to provide an experimental basis for prevention and treatment of hypertensive LVH. Fifty eight hypertensive patients and 14 healthy controls were studied....

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Veröffentlicht in:Hypertension Research 2000, Vol.23(4), pp.377-380
Hauptverfasser: HUA, Liyan, LI, Changyu, XIA, Daozi, QU, Peng, LI, Zhongyan, ZHANG, Weijiang, FENG, Xiaohai
Format: Artikel
Sprache:eng
Schlagworte:
Adult
endothelin
Endothelins - blood
Female
Humans
hypertension
Hypertension - blood
Hypertension - complications
Hypertrophy, Left Ventricular - etiology
left ventricular hypertrophy
Male
Middle Aged
nitric oxide
Nitric Oxide - blood
Regression Analysis
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Zusammenfassung:To investigate the relationship between hypertensive left ventricular hypertrophy (LVH) and levels of endothelin (ET) and nitric oxide (NO), and to provide an experimental basis for prevention and treatment of hypertensive LVH. Fifty eight hypertensive patients and 14 healthy controls were studied. All patients were examined by echocardiography. Left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated using Devereux RB formula. Hypertensive patients were divided into a LVH (+) group (n=21) and a LVH (-) group (n=37), and the levels of endothelin and nitric oxide in the peripheral venous blood were measured. The mean ET level was significantly higher in the LVH (+) group than in LVH (-) group (p
ISSN:0916-9636
1348-4214
DOI:10.1291/hypres.23.377