Stepwise specification of lymphocyte developmental lineages

B and T lymphocytes differentiate from multipotent precursors through distinct specification and commitment steps. New findings on the unique role of Pax5 in B-lineage commitment, dichotomous action of Notch signaling in B versus T cell development, and the gene expression changes comprising T-linea...

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Veröffentlicht in:	Current Opinion in Genetics & Development 2000-08, Vol.10 (4), p.370-379
1. Verfasser:	Rothenberg, Ellen V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-cell development B-Lymphocytes - cytology bHLH Cell Differentiation Cell Lineage Commitment Dendritic cell DNA-Binding Proteins - metabolism Hematopoietic Stem Cells - cytology Humans Membrane Proteins - physiology Natural cell killer Notch Notch protein Pax5 Pax5 protein PAX5 Transcription Factor Proteins - metabolism PU.1 Receptors, Notch T-cell development T-Lymphocytes - cytology Thymus Gland - cytology Trans-Activators - metabolism Transcription factor Transcription Factors
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Beschreibung
Zusammenfassung:	B and T lymphocytes differentiate from multipotent precursors through distinct specification and commitment steps. New findings on the unique role of Pax5 in B-lineage commitment, dichotomous action of Notch signaling in B versus T cell development, and the gene expression changes comprising T-lineage specification and commitment now illuminate this process.
ISSN:	0959-437X 1879-0380
DOI:	10.1016/S0959-437X(00)00098-8