Parallel synthesis and evaluation of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines as Na +/K + ATPase inhibitors

A series of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines was prepared using solution-phase, parallel synthesis and evaluated for Na +/K + ATPase inhibition.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-07, Vol.10 (14), p.1543-1545
Hauptverfasser:	Blass, Benjamin E., Huang, C.T., Kawamoto, Richard M., Li, Min, Liu, Song, Portlock, David E., Rennells, William M., Simmons, Melanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemical synthesis Amines - chemistry Amines - pharmacology Animals Biological and medical sciences Cardiovascular system Dogs Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Indicators and Reagents Kinetics Medical sciences Miscellaneous Molecular Conformation Molecular Structure Myocardium - enzymology Pharmacology. Drug treatments Sarcolemma - enzymology Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	A series of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines was prepared using solution-phase, parallel synthesis and evaluated for Na +/K + ATPase inhibition.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00296-1