Elevated circulating homocyst(e)ine levels in placental vascular disease and associated pre‐eclampsia

We examined the hypothesis that hyperhomocyst(e)inaemia in the maternal or fetal circulation is associated with placental vascular disease with either the maternal syndrome of pre‐eclampsia and/or fetal syndrome of growth restriction. Maternal plasma homocyst(e)ine levels were significantly higher i...

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Veröffentlicht in:BJOG : an international journal of obstetrics and gynaecology 2000-07, Vol.107 (7), p.935-938
Hauptverfasser: Wang, Jian, Trudinger, Brian J., Duarte, Natalia, Wilcken, David E., Li Wang, Xing
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Sprache:eng
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Zusammenfassung:We examined the hypothesis that hyperhomocyst(e)inaemia in the maternal or fetal circulation is associated with placental vascular disease with either the maternal syndrome of pre‐eclampsia and/or fetal syndrome of growth restriction. Maternal plasma homocyst(e)ine levels were significantly higher in pregnancies complicated by pre‐eclampsia, pregnancies with evidence of umbilical placental vascular disease, and pregnancies with both complications compared with the normal pregnancy group. In the fetal circulation mean plasma homocyst(e)ine concentration was significantly higher in the pre‐eclampsia group compared with the normal group. The results suggest that hyperhomocyst(e)inaemia may be a risk marker for placental vascular disease and maternal pre‐eclampsia. The elevated fetal plasma homocyst(e)ine concentrations, found only in the group of pregnancies with pre‐eclampsia in the absence of umbilical placental vascular disease, may be due to an effect of placental vascular disease on homocyst(e)ine transfer from the maternal to fetal circulation.
ISSN:1470-0328
0306-5456
1471-0528
1365-215X
DOI:10.1111/j.1471-0528.2000.tb11095.x