Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons

The olfactory ensheathing cell (OEC) has attracted much interest recently because of its potential for transplantation-based therapy of CNS disease. Rat OECs are able to remyelinate demyelinated axons and support regeneration of damaged axons. Although OECs can be grown readily from the rat, a macro...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2000-08, Vol.123 (8), p.1581-1588
Hauptverfasser:	Barnett, Susan C., Alexander, Claire L., Iwashita, Yasushi, Gilson, Jennifer M., Crowther, John, Clark, Louise, Dunn, Laurence T., Papanastassiou, Vakis, Kennedy, Peter G. E., Franklin, Robin J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACM = astrocyte conditioned medium Animals Axons - physiology Biological and medical sciences BrdU = bromodeoxyuridine BS = Bottenstein and Sato Cells, Cultured Demyelinating Diseases - surgery demyelination DMEM = Dulbecco's modified Eagle's medium EB = ethidium bromide FCS = foetal calf serum Female Fundamental and applied biological sciences. Psychology GFAP = glial fibrillary acidic protein growth factors Growth Substances - physiology hOEC = human olfactory ensheathing cell Humans Isolated neuron and nerve. Neuroglia L-NGFr = low-affinity nerve growth factor receptor Myelin Sheath - physiology Neuroglia - metabolism Neuroglia - transplantation OEC = olfactory ensheathing cell Olfactory Bulb - cytology rat Rats Rats, Nude Rats, Sprague-Dawley Receptor, Nerve Growth Factor - metabolism rOEC = rat olfactory ensheathing cell Spinal Cord Diseases - surgery transplantation Transplantation, Heterologous Vertebrates: nervous system and sense organs VWF = von Willebrand's factor X-EB = X-irradiated ethidium bromide
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