Exercise Training Enhances Glycolytic and Oxidative Enzymes in Canine Ventricular Myocardium

S. R. Stuewe, P. A. Gwirtz, N. Agarwal and R. T. Mallet. Exercise Training Enhances Glycolytic and Oxidative Enzymes in Canine Ventricular Myocardium. Journal of Molecular and Cellular Cardiology (2000) 32, 903–913. Aerobic exercise training evokes adaptations in the myocardial contractile machinery that enhance cardiac functional capacity; in comparison, the effects of training on the myocardium's energy generating pathways are less well characterized. This study tested the hypothesis that aerobic exercise training can increase the capacities of the major pathways of intermediary metabolism in canine myocardium. Mongrel dogs were conditioned by a 9-week treadmill running program or cage rested for 4 weeks. Exercise conditioning was evidenced by 26% and 22% decreases (P