Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 4: Variation of the basic structure

Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 4: Variation of the basic structure

A range of 11 derivatives of flavone-8-acetic acid (FAA) in which the structure has been substantially altered in different ways have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. The generally poor...

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Veröffentlicht in:Archiv der Pharmazie (Weinheim) 2000-06, Vol.333 (6), p.181-188
Hauptverfasser: Aitken, R A, Bibby, M C, Cooper, P A, Double, J A, Laws, A L, Ritchie, R B, Wilson, D W
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Flavonoids - chemical synthesis
Flavonoids - pharmacology
Humans
Mice
Structure-Activity Relationship
Tumor Cells, Cultured
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Zusammenfassung:A range of 11 derivatives of flavone-8-acetic acid (FAA) in which the structure has been substantially altered in different ways have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. The generally poor activity observed shows that the basic structure cannot be altered much without destroying the activity.
ISSN:0365-6233
DOI:10.1002/1521-4184(20006)333:6<181::AID-ARDP181>3.0.CO;2-O