Synthesis and
anti‐aggregatory activity of linear retro‐inverso RGD peptides

: Six retro‐inverso tri‐ and tetrapeptide analogues of RGD were prepared and their anti‐aggregatory activity was determined by platelet aggregation tests in comparison with the corresponding parent peptides. An efficient method for the introduction of a malonyl‐aspartic residue into a peptide chain is described for the first time. A 2–3‐fold decrease in potency or total loss of bioactivity was observed with the new peptides; structure–activity relationships are discussed.