Assignment of the human RhoHP1 gene (ARHD) to chromosome 11q14.3 by radiation hybrid mapping

Assignment of the human RhoHP1 gene (ARHD) to chromosome 11q14.3 by radiation hybrid mapping

The Rho (represents Ras homologous) related protein HP1 (RhoHP1) was isolated from a human placenta cDNA library. RhoHP1 showed 50-54% sequence homology to members of the Rho family. The Rho proteins directly interact with protein kinases, which may serve as downstream effector targets of the activa...

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Veröffentlicht in:Cytogenetics and cell genetics 2000, Vol.89 (1-2), p.53-53
Hauptverfasser: Kim, H S, Choi, J Y, Jung, A R, Jang, K L, Lee, W H, Choi, W C, Crow, T J, Hyun, B H
Format: Artikel
Sprache:eng
Schlagworte:
ARHD gene
chromosome 11
Chromosome Mapping
Chromosomes, Human, Pair 11 - genetics
Humans
Hybrid Cells
Lod Score
Polymerase Chain Reaction
rho GTP-Binding Proteins - genetics
RhoHP1 gene
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Beschreibung
Zusammenfassung:The Rho (represents Ras homologous) related protein HP1 (RhoHP1) was isolated from a human placenta cDNA library. RhoHP1 showed 50-54% sequence homology to members of the Rho family. The Rho proteins directly interact with protein kinases, which may serve as downstream effector targets of the activated GTPase. The Rho family proteins play a critical role in muscle differentiation by regulating the expression of the myogenin and MEF2 genes. In this report, a radiation hybrid mapping panel was used to assign the RhoHP1 gene ARHD (ras homolog gene family, member D) to chromosome 11q14.3.
ISSN:0301-0171
DOI:10.1159/000015562