Hyperglycaemia alters the endothelium-dependent relaxation of canine coronary arteries

The aim of the present study was to investigate the effects of experimental diabetes and hyperglycaemia per se on the endothelium‐dependent relaxation of isolated canine coronary arteries and to analyse the possible involvement of the cyclooxygenase pathway in the alterations induced by hyperglycaem...

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Veröffentlicht in:	Acta physiologica Scandinavica 2000-07, Vol.169 (3), p.183-187
Hauptverfasser:	KOCSIS, E, PACHER, P, POSA, I, NIESZNER, E, POGATSA, G, KOLTAI, M. Z
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholine - pharmacology Animals Associated diseases and complications Biological and medical sciences Blood Glucose coronary artery Coronary Vessels - metabolism Coronary Vessels - physiopathology Cyclooxygenase Inhibitors - pharmacology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Dinoprost - pharmacology dog Dogs Endocrine pancreas. Apud cells (diseases) Endocrinopathies endothelium Endothelium, Vascular - metabolism Enzyme Inhibitors - pharmacology experimental diabetes Female hyperglycaemia Hyperglycemia - metabolism in vitro In Vitro Techniques Indomethacin - pharmacology Male Medical sciences Nitroarginine - pharmacology Nitroprusside - pharmacology Osmolar Concentration Vasoconstriction - drug effects Vasodilation - drug effects Vasodilator Agents - pharmacology
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Zusammenfassung:	The aim of the present study was to investigate the effects of experimental diabetes and hyperglycaemia per se on the endothelium‐dependent relaxation of isolated canine coronary arteries and to analyse the possible involvement of the cyclooxygenase pathway in the alterations induced by hyperglycaemia. Rings from the left anterior descending coronary arteries of 18 metabolically healthy, six alloxan‐diabetic and six insulin‐treated alloxan diabetic dogs were set up for isometric tension recording. Diabetic coronaries as well as healthy vessels subjected to in vitro hyperglycaemia (25.5 mmol L–1 glucose) showed impaired (P
ISSN:	0001-6772 1365-201X
DOI:	10.1046/j.1365-201x.2000.00731.x