Evidence of oxidative stress in asthma and COPD: potential inhibitory effect of theophylline

To evaluate the potential inhibitory effect of theophylline on the pulmonary oxidative stress in asthma and chronic obstructive pulmonary disease (COPD), we concomitantly measured the blood levels of theophylline, a non-selective phosphodiesterase (PDE) inhibitor and lipid peroxides as an index of o...

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Veröffentlicht in:	Respiratory medicine 2000-06, Vol.94 (6), p.584-588
Hauptverfasser:	TSUKAGOSHI, H, SHIMIZU, Y, IWAMAE, S, HISADA, T, ISHIZUKA, T, IIZUKA, K, DOBASHI, K, MORI, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged asthma Asthma - drug therapy Asthma - physiopathology Biological and medical sciences chronic obstructive pulmonary disease (COPD) Female Forced Expiratory Volume - drug effects Humans lipid peroxides Lipid Peroxides - blood Lung Diseases, Obstructive - drug therapy Lung Diseases, Obstructive - physiopathology Male Medical sciences Middle Aged Oxidative Stress - drug effects Pharmacology. Drug treatments phosphodiesterase (PDE) Phosphodiesterase Inhibitors - blood pulmonary oxidative stress Respiratory system theophylline Theophylline - blood Theophylline - therapeutic use Vital Capacity - drug effects
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Zusammenfassung:	To evaluate the potential inhibitory effect of theophylline on the pulmonary oxidative stress in asthma and chronic obstructive pulmonary disease (COPD), we concomitantly measured the blood levels of theophylline, a non-selective phosphodiesterase (PDE) inhibitor and lipid peroxides as an index of oxidative stress. The plasma levels of lipid peroxides were significantly elevated in patients with asthma (3·48±0·11 nmol ml−1; mean±SEM;n=21, P
ISSN:	0954-6111 1532-3064
DOI:	10.1053/rmed.2000.0785