Identification of Inhibitors of Inducible Nitric Oxide Synthase from Microbial Extracts

A new member of the angucycline family, vineomycin C (3), together with four known metabolites saquayamycin Al (1), A-7884 (2), rabelomycin (5) and xanthomegnin (6) were isolated from microbial extracts. The structures were determined by ID and 2D NMR techniques and chemical degradation. Compounds 1...

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Veröffentlicht in:	Journal of antibiotics 2000/05/25, Vol.53(5), pp.496-501
Hauptverfasser:	ALVI, KHISAL A., BAKER, DWIGHT D., STIENECKER, VAUGHN, HOSKEN, MARGARET, NAIR, BIPIN G.
Format:	Artikel
Sprache:	eng
Schlagworte:	AA-78848 Animals Anthraquinones - chemistry Anthraquinones - isolation & purification Anthraquinones - pharmacology Antibacterial agents Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Applied microbiology Biological and medical sciences Cell Line Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Magnetic Resonance Spectroscopy Medical sciences Mice Microbiology Molecular Structure Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type II Pharmacology. Drug treatments rabelomycin saquayamycin A1 Spectrum Analysis Streptomyces - chemistry vineomycin C xanthomegnin
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Zusammenfassung:	A new member of the angucycline family, vineomycin C (3), together with four known metabolites saquayamycin Al (1), A-7884 (2), rabelomycin (5) and xanthomegnin (6) were isolated from microbial extracts. The structures were determined by ID and 2D NMR techniques and chemical degradation. Compounds 1-3 and 5 were isolated from a fermentation of Streptomyces sp., while 6 was isolated from a fungal fermentation extract. All five compounds have shown potent inhibitory activity in the inducible nitric oxide synthase (iNOS) assay.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.53.496