Syntheses and antifilarial profile of 7-chloro-4-(substituted amino) quinolines: a new class of antifilarial agents

The syntheses of 7-chloro-4-(substituted amino) quinolines ( 2– 22) and their antifilarial activities are delineated. Some of the screened compounds have shown promising filarial response and sterilization effect on female Acanthocheilonema viteae in rodents.

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-07, Vol.10 (13), p.1409-1412
Hauptverfasser:	Tewari, Swati, Chauhan, P.M.S, Bhaduri, A.P, Fatima, Nigar, Chatterjee, R.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines - chemistry Aminoquinolines - pharmacology Aminoquinolines - therapeutic use Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Chemistry, Pharmaceutical Dipetalonema - drug effects Dipetalonema Infections - drug therapy Drug Evaluation, Preclinical Female Filaricides - chemistry Filaricides - pharmacology Filaricides - therapeutic use Medical sciences Molecular Structure Muridae Pharmacology. Drug treatments
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Beschreibung
Zusammenfassung:	The syntheses of 7-chloro-4-(substituted amino) quinolines ( 2– 22) and their antifilarial activities are delineated. Some of the screened compounds have shown promising filarial response and sterilization effect on female Acanthocheilonema viteae in rodents.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(00)00255-9