The pharmacokinetics and metabolism of sucralose in the rabbit

The excretion and metabolism of 14C-sucralose has been investigated in non-pregnant and pregnant rabbits after administration of single 10 mg/kg oral doses. Means of 22% and 55% of the dose were excreted in urine and faeces, respectively, by non-pregnant animals during 5 days. Excretion was similar...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Food and chemical toxicology 2000-01, Vol.38, p.111-113
Hauptverfasser: John, B.A, Wood, S.G, Hawkins, D.R
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The excretion and metabolism of 14C-sucralose has been investigated in non-pregnant and pregnant rabbits after administration of single 10 mg/kg oral doses. Means of 22% and 55% of the dose were excreted in urine and faeces, respectively, by non-pregnant animals during 5 days. Excretion was similar in pregnant animals with means of 22% and 65% of the dose in urine and faeces, respectively, during the same time. Following a single oral dose, a mean of approximately 7% of the dose was still being excreted during the 96–120-hr collection period. Only one major radioactive component was detected in urine samples which corresponded to unchanged sucralose.
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(00)00033-8