Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease

Thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation, were assayed in postmortem brain. Basal TBARS levels were increased and oxidative stimulation produced more TBARS in AD relative to control brains. In addition, apolipoprotein E isoforms showed differing antioxidant act...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurology 2000-06, Vol.54 (12), p.2319-2321
Hauptverfasser:	TAMAOKA, A, MIYATAKE, F, TAKAHASHI, H, SHOJI, S, MATSUNO, S, ISHII, K, NAGASE, S, SAHARA, N, ONO, S, MORI, H, WAKABAYASHI, K, TSUJI, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Antioxidants - chemistry Antioxidants - metabolism Apolipoproteins E - chemistry Apolipoproteins E - metabolism Biological and medical sciences Brain Chemistry Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Ferrous Compounds - chemistry Humans Hydrogen Peroxide - chemistry Lipid Peroxidation Male Medical sciences Neurology Oxidation-Reduction Reference Values Temporal Lobe - metabolism Temporal Lobe - pathology Thiobarbituric Acid Reactive Substances - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation, were assayed in postmortem brain. Basal TBARS levels were increased and oxidative stimulation produced more TBARS in AD relative to control brains. In addition, apolipoprotein E isoforms showed differing antioxidant activities, with E2 > E3 > E4, suggesting that the lowest antioxidant activity of E4 could contribute to its association with AD.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.54.12.2319