New antineoplastic prenylhydroquinones. Synthesis and evaluation

Several prenylhydroquinones have been prepared through Diels-Alder condensation, further functionalized or degraded chemically and then evaluated for their cytotoxic activity against some neoplastic cultured cell lines. A number of them have shown IC50 values under the microM level.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2000-05, Vol.8 (5), p.1027-1032
Hauptverfasser:	MOLINARI, A, OLIVA, A, AGUILERA, A. N, MIGUEL DEL CORRAL, J. M, CASTRO, M. A, GORDALIZA, M, GARCIA-GRAVALOS, D, SAN FELICIANO, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor General aspects Humans Hydroquinones - chemical synthesis Hydroquinones - chemistry Hydroquinones - pharmacology Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Pharmacology. Drug treatments Spectroscopy, Fourier Transform Infrared Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Several prenylhydroquinones have been prepared through Diels-Alder condensation, further functionalized or degraded chemically and then evaluated for their cytotoxic activity against some neoplastic cultured cell lines. A number of them have shown IC50 values under the microM level.
ISSN:	0968-0896 1464-3391
DOI:	10.1016/S0968-0896(00)00032-8