INHIBITION OF HMG-CoA REDUCTASE ACTIVITY BY HYPERCHOLESTEROLAEMIA REDUCES LEUKOCYTE RECRUITMENT AND MCP-1 PRODUCTION

To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recuitment by inhibiting int...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2000-07, Vol.12 (7), p.1100-1103
Hauptverfasser:	Fruscella, Paolo, Romano, Maria, Albani, Diego, Bernasconi, Sergio, Luini, Walter, Bruno, Alessandra, Salmona, Mario, Diomede, Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CCAAT-Enhancer-Binding Proteins Cell Movement - immunology Chemokine CCL2 - biosynthesis chemokines/cholesterol/HMG-CoA reductase/MCP-1/rodent Cholesterol - immunology DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - immunology Hydroxymethylglutaryl CoA Reductases - physiology Hypercholesterolemia - enzymology Hypercholesterolemia - immunology Leukocytes - immunology Leukocytes - physiology Male Mice Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - immunology Sterol Regulatory Element Binding Protein 1 Transcription Factors
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Zusammenfassung:	To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recuitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility.
ISSN:	1043-4666 1096-0023
DOI:	10.1006/cyto.1999.0602