Local Versus Systemic Adjunctive Antibiotic Therapy in 28 Patients With Generalized Aggressive Periodontitis

Background: Although the use of systemic antibiotics has been studied in patients with generalized aggressive periodontitis (formerly rapidly progressive periodontitis), the use of adjunctive tetracycline fibers in these patients has not been reported. The purpose of the present study was to compare...

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Veröffentlicht in:Journal of periodontology (1970) 2001-09, Vol.72 (9), p.1241-1245
Hauptverfasser: Purucker, Peter, Mertes, Helmut, Goodson, J. Max, Bernimoulin, Jean‐Pierre
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container_end_page 1245
container_issue 9
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container_title Journal of periodontology (1970)
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creator Purucker, Peter
Mertes, Helmut
Goodson, J. Max
Bernimoulin, Jean‐Pierre
description Background: Although the use of systemic antibiotics has been studied in patients with generalized aggressive periodontitis (formerly rapidly progressive periodontitis), the use of adjunctive tetracycline fibers in these patients has not been reported. The purpose of the present study was to compare the clinical response of local versus systemic antibiotic treatment as adjuncts to scaling and root planing in patients with GAgP. Methods: After initial therapy and full‐mouth scaling and root planing (SRP), 30 patients were randomly assigned to 1 of 2 antibiotic treatment groups. Probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were recorded with an automated probe prior to SRP at baseline (BL) and 15, 30, 41, and 54 weeks later. Three months after SRP, the patients were treated with amoxicillin/clavulanic acid (500 mg tid; SRP + AUG group) or with local tetracycline fiber in pockets with PD ≥5 mm (SRP + TCF group). Results: In both treatment groups, PD decreased significantly from BL to week 54 (6.2 ± 1.5 mm to 4.7 ± 1.4 mm for SRP + TCF and 6.5 ± 1.4 mm to 4.2 ± 0.6 mm for SRP + AUG). However, there was no statistically significant difference between the 2 groups in pocket reduction. Similarly, in both treatment groups, there were small but significant gains in CAL from BL to week 54 (12.0 ± 1.8 mm to 11.3 ± 1.8 mm for SRP + TCF and 12.3 ± 1.5 mm to 11.2 ± 1.2 mm for SRP + AUG). The difference in CAL gain between the 2 groups was not statistically significant. At the final examination, both groups showed significant PD reduction and CAL gain (P
doi_str_mv 10.1902/jop.2000.72.9.1241
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Max ; Bernimoulin, Jean‐Pierre</creator><creatorcontrib>Purucker, Peter ; Mertes, Helmut ; Goodson, J. Max ; Bernimoulin, Jean‐Pierre</creatorcontrib><description>Background: Although the use of systemic antibiotics has been studied in patients with generalized aggressive periodontitis (formerly rapidly progressive periodontitis), the use of adjunctive tetracycline fibers in these patients has not been reported. The purpose of the present study was to compare the clinical response of local versus systemic antibiotic treatment as adjuncts to scaling and root planing in patients with GAgP. Methods: After initial therapy and full‐mouth scaling and root planing (SRP), 30 patients were randomly assigned to 1 of 2 antibiotic treatment groups. Probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were recorded with an automated probe prior to SRP at baseline (BL) and 15, 30, 41, and 54 weeks later. Three months after SRP, the patients were treated with amoxicillin/clavulanic acid (500 mg tid; SRP + AUG group) or with local tetracycline fiber in pockets with PD ≥5 mm (SRP + TCF group). Results: In both treatment groups, PD decreased significantly from BL to week 54 (6.2 ± 1.5 mm to 4.7 ± 1.4 mm for SRP + TCF and 6.5 ± 1.4 mm to 4.2 ± 0.6 mm for SRP + AUG). However, there was no statistically significant difference between the 2 groups in pocket reduction. Similarly, in both treatment groups, there were small but significant gains in CAL from BL to week 54 (12.0 ± 1.8 mm to 11.3 ± 1.8 mm for SRP + TCF and 12.3 ± 1.5 mm to 11.2 ± 1.2 mm for SRP + AUG). The difference in CAL gain between the 2 groups was not statistically significant. At the final examination, both groups showed significant PD reduction and CAL gain (P &lt;0.001) compared to BL. The frequency and percentage of bleeding sites decreased significantly in both groups. At week 54, this decrease was significantly greater in the SRP + AUG group (31.67% for SRP + TCF versus 3.85% for SRP + AUG). Conclusions: These results indicate that the local delivery of tetracycline by a fiber or the systemic administration of amoxicillin/clavulanic acid given 3 months after scaling and root planing produced similar clinical outcomes over the 9‐month observation period. J Periodontol 2001;72:1241‐1245.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1902/jop.2000.72.9.1241</identifier><identifier>PMID: 11577957</identifier><language>eng</language><publisher>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA: American Academy of Periodontology</publisher><subject>Administration, Oral ; Administration, Topical ; Adult ; Aggressive Periodontitis - drug therapy ; Amoxicillin-Potassium Clavulanate Combination - administration &amp; dosage ; Anti-Bacterial Agents - administration &amp; dosage ; Antibiotics/therapeutic use ; Dental Scaling ; Dentistry ; Drug Therapy, Combination - administration &amp; dosage ; Humans ; periodontal diseases/therapy ; Periodontal Index ; Periodontitis - drug therapy ; periodontitis/therapy ; Statistics, Nonparametric ; Tetracycline - administration &amp; dosage ; tetracycline/therapeutic use</subject><ispartof>Journal of periodontology (1970), 2001-09, Vol.72 (9), p.1241-1245</ispartof><rights>2001 American Academy of Periodontology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3481-d366305f57ec6150e3d442fd7d46c17405c8bf7be792a992f9e009897fd032203</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1902%2Fjop.2000.72.9.1241$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1902%2Fjop.2000.72.9.1241$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11577957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Purucker, Peter</creatorcontrib><creatorcontrib>Mertes, Helmut</creatorcontrib><creatorcontrib>Goodson, J. Max</creatorcontrib><creatorcontrib>Bernimoulin, Jean‐Pierre</creatorcontrib><title>Local Versus Systemic Adjunctive Antibiotic Therapy in 28 Patients With Generalized Aggressive Periodontitis</title><title>Journal of periodontology (1970)</title><addtitle>J Periodontol</addtitle><description>Background: Although the use of systemic antibiotics has been studied in patients with generalized aggressive periodontitis (formerly rapidly progressive periodontitis), the use of adjunctive tetracycline fibers in these patients has not been reported. The purpose of the present study was to compare the clinical response of local versus systemic antibiotic treatment as adjuncts to scaling and root planing in patients with GAgP. Methods: After initial therapy and full‐mouth scaling and root planing (SRP), 30 patients were randomly assigned to 1 of 2 antibiotic treatment groups. Probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were recorded with an automated probe prior to SRP at baseline (BL) and 15, 30, 41, and 54 weeks later. Three months after SRP, the patients were treated with amoxicillin/clavulanic acid (500 mg tid; SRP + AUG group) or with local tetracycline fiber in pockets with PD ≥5 mm (SRP + TCF group). Results: In both treatment groups, PD decreased significantly from BL to week 54 (6.2 ± 1.5 mm to 4.7 ± 1.4 mm for SRP + TCF and 6.5 ± 1.4 mm to 4.2 ± 0.6 mm for SRP + AUG). However, there was no statistically significant difference between the 2 groups in pocket reduction. Similarly, in both treatment groups, there were small but significant gains in CAL from BL to week 54 (12.0 ± 1.8 mm to 11.3 ± 1.8 mm for SRP + TCF and 12.3 ± 1.5 mm to 11.2 ± 1.2 mm for SRP + AUG). The difference in CAL gain between the 2 groups was not statistically significant. At the final examination, both groups showed significant PD reduction and CAL gain (P &lt;0.001) compared to BL. The frequency and percentage of bleeding sites decreased significantly in both groups. At week 54, this decrease was significantly greater in the SRP + AUG group (31.67% for SRP + TCF versus 3.85% for SRP + AUG). Conclusions: These results indicate that the local delivery of tetracycline by a fiber or the systemic administration of amoxicillin/clavulanic acid given 3 months after scaling and root planing produced similar clinical outcomes over the 9‐month observation period. 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Max</creator><creator>Bernimoulin, Jean‐Pierre</creator><general>American Academy of Periodontology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200109</creationdate><title>Local Versus Systemic Adjunctive Antibiotic Therapy in 28 Patients With Generalized Aggressive Periodontitis</title><author>Purucker, Peter ; Mertes, Helmut ; Goodson, J. Max ; Bernimoulin, Jean‐Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3481-d366305f57ec6150e3d442fd7d46c17405c8bf7be792a992f9e009897fd032203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Administration, Topical</topic><topic>Adult</topic><topic>Aggressive Periodontitis - drug therapy</topic><topic>Amoxicillin-Potassium Clavulanate Combination - administration &amp; dosage</topic><topic>Anti-Bacterial Agents - administration &amp; dosage</topic><topic>Antibiotics/therapeutic use</topic><topic>Dental Scaling</topic><topic>Dentistry</topic><topic>Drug Therapy, Combination - administration &amp; dosage</topic><topic>Humans</topic><topic>periodontal diseases/therapy</topic><topic>Periodontal Index</topic><topic>Periodontitis - drug therapy</topic><topic>periodontitis/therapy</topic><topic>Statistics, Nonparametric</topic><topic>Tetracycline - administration &amp; dosage</topic><topic>tetracycline/therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Purucker, Peter</creatorcontrib><creatorcontrib>Mertes, Helmut</creatorcontrib><creatorcontrib>Goodson, J. Max</creatorcontrib><creatorcontrib>Bernimoulin, Jean‐Pierre</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Purucker, Peter</au><au>Mertes, Helmut</au><au>Goodson, J. Max</au><au>Bernimoulin, Jean‐Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local Versus Systemic Adjunctive Antibiotic Therapy in 28 Patients With Generalized Aggressive Periodontitis</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>2001-09</date><risdate>2001</risdate><volume>72</volume><issue>9</issue><spage>1241</spage><epage>1245</epage><pages>1241-1245</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background: Although the use of systemic antibiotics has been studied in patients with generalized aggressive periodontitis (formerly rapidly progressive periodontitis), the use of adjunctive tetracycline fibers in these patients has not been reported. The purpose of the present study was to compare the clinical response of local versus systemic antibiotic treatment as adjuncts to scaling and root planing in patients with GAgP. Methods: After initial therapy and full‐mouth scaling and root planing (SRP), 30 patients were randomly assigned to 1 of 2 antibiotic treatment groups. Probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were recorded with an automated probe prior to SRP at baseline (BL) and 15, 30, 41, and 54 weeks later. Three months after SRP, the patients were treated with amoxicillin/clavulanic acid (500 mg tid; SRP + AUG group) or with local tetracycline fiber in pockets with PD ≥5 mm (SRP + TCF group). Results: In both treatment groups, PD decreased significantly from BL to week 54 (6.2 ± 1.5 mm to 4.7 ± 1.4 mm for SRP + TCF and 6.5 ± 1.4 mm to 4.2 ± 0.6 mm for SRP + AUG). However, there was no statistically significant difference between the 2 groups in pocket reduction. Similarly, in both treatment groups, there were small but significant gains in CAL from BL to week 54 (12.0 ± 1.8 mm to 11.3 ± 1.8 mm for SRP + TCF and 12.3 ± 1.5 mm to 11.2 ± 1.2 mm for SRP + AUG). The difference in CAL gain between the 2 groups was not statistically significant. At the final examination, both groups showed significant PD reduction and CAL gain (P &lt;0.001) compared to BL. The frequency and percentage of bleeding sites decreased significantly in both groups. At week 54, this decrease was significantly greater in the SRP + AUG group (31.67% for SRP + TCF versus 3.85% for SRP + AUG). Conclusions: These results indicate that the local delivery of tetracycline by a fiber or the systemic administration of amoxicillin/clavulanic acid given 3 months after scaling and root planing produced similar clinical outcomes over the 9‐month observation period. J Periodontol 2001;72:1241‐1245.</abstract><cop>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA</cop><pub>American Academy of Periodontology</pub><pmid>11577957</pmid><doi>10.1902/jop.2000.72.9.1241</doi><tpages>5</tpages></addata></record>
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subjects Administration, Oral
Administration, Topical
Adult
Aggressive Periodontitis - drug therapy
Amoxicillin-Potassium Clavulanate Combination - administration & dosage
Anti-Bacterial Agents - administration & dosage
Antibiotics/therapeutic use
Dental Scaling
Dentistry
Drug Therapy, Combination - administration & dosage
Humans
periodontal diseases/therapy
Periodontal Index
Periodontitis - drug therapy
periodontitis/therapy
Statistics, Nonparametric
Tetracycline - administration & dosage
tetracycline/therapeutic use
title Local Versus Systemic Adjunctive Antibiotic Therapy in 28 Patients With Generalized Aggressive Periodontitis
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