Radial Glial Cells: Are They Really Glia?

During the development of the cerebral cortex, radial glia serve as a scaffold to support and direct neurons during their migration. This view is now changing in the light of emerging evidence showing that these cells have a much more dynamic and diverse role. A recent series of studies has provided...

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Veröffentlicht in:	Neuron 2001-09, Vol.31 (6), p.881-884
Hauptverfasser:	Parnavelas, John G., Nadarajah, Bagirathy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - chemistry Astrocytes - classification Astrocytes - cytology Biomarkers - analysis Birds - anatomy & histology Birds - embryology Cell Differentiation Cell Lineage Central Nervous System - cytology Central Nervous System - embryology Cerebral Cortex - cytology Cerebral Cortex - embryology Chick Embryo Genes, Reporter Glial Fibrillary Acidic Protein - genetics Green Fluorescent Proteins Humans Luminescent Proteins - analysis Mammals - anatomy & histology Mammals - embryology Mice Mice, Transgenic Nerve Tissue Proteins - analysis Neurons - cytology Rats Recombinant Fusion Proteins - analysis Stem Cells - cytology
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Beschreibung
Zusammenfassung:	During the development of the cerebral cortex, radial glia serve as a scaffold to support and direct neurons during their migration. This view is now changing in the light of emerging evidence showing that these cells have a much more dynamic and diverse role. A recent series of studies has provided strong support for their role as precursor cells in the ventricular zone that generate cortical neurons and glia, in addition to providing migration guidance.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/S0896-6273(01)00437-8