Effect of cernitin pollen-extract on experimental nonbacterial prostatitis in rats

Background The treatment for chronic nonbacterial prostatitis (NBP) has not been established. Cernitin pollen‐extract (CN‐009) is reported to have therapeutic effects for NBP. The effects and mechanisms of CN‐009 were investigated. Methods Ten‐month‐old rats were used with administration of estradiol after castration, which were similar to human NBP histologically. Since CN‐009 consists of T‐60 and GBX, these drugs were administered, respectively. The prostate was evaluated histopathologically including glandular damage (epithelial score), stromal ratio and immunohistochemical assays for epithelial function (PAP), stromal evaluation (Vimentin), cell proliferation (PCNA) and apoptosis (deoxyuridine triphosphate biotin nick end‐labeling (TUNEL)). Results Controls revealed severe acinar gland atrophy and stromal proliferation. CN‐009 showed diminished these damages. Epithelial score was better (P