Immunosenescence and infectious diseases

Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficien...

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Veröffentlicht in:	Microbes and Infection 2001-08, Vol.3 (10), p.851-857
Hauptverfasser:	Ginaldi, Lia, Loreto, Maria Francesca, Corsi, Maria Pia, Modesti, Marco, De Martinis, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - immunology Animals Biological and medical sciences Communicable Diseases - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects. Ontogeny. Phylogeny Humans Immune System Immunobiology immunosenescence infectious diseases Vaccines - immunology
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Beschreibung
Zusammenfassung:	Infectious diseases are major causes, with malignancies, of morbidity and mortality in the elderly. Increased susceptibility to infections may result from underlying dysfunction of an aged immune system; moreover, inappropriate immunologic functions associated with aging can determine an insufficient response to vaccines. Impairments of cellular, humoral and innate immunity in the elderly, contributing to increased incidence of infectious diseases, are discussed in this review.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/S1286-4579(01)01443-5