The renaissance of GSK3

Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of cell functions. The study of the substrate specificity and regulation of GSK3 activity has been important in the quest for therapeutic interventi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature reviews. Molecular cell biology 2001-10, Vol.2 (10), p.769-776
Hauptverfasser:	Cohen, Philip, Frame, Sheelagh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cancer Research Cell Biology Cell division Developmental Biology Diabetes Diabetes Mellitus, Type 2 - physiopathology Drosophila melanogaster - embryology Embryo, Nonmammalian - physiology Enzyme Inhibitors - pharmacology Enzymes Glucose Glycogen - biosynthesis Glycogen Synthase Kinases Humans Insulin - physiology Insulin resistance Kinases Life Sciences Metabolism Phosphorylation Protein Biosynthesis Proteins Signal Transduction Stem Cells Substrate Specificity timeline
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of cell functions. The study of the substrate specificity and regulation of GSK3 activity has been important in the quest for therapeutic intervention.
ISSN:	1471-0072 1471-0080
DOI:	10.1038/35096075