IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms

IgA is the most abundant immunoglobulin produced in mammals; most is secreted as a dimer across mucous membranes. This review discusses the different mechanisms of induction of IgA, and its role in protecting mucosal surfaces against pathogenic and non-pathogenic microorganisms.

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Bibliographische Detailangaben
Veröffentlicht in:	Microbes and Infection 2001-10, Vol.3 (12), p.1021-1035
Hauptverfasser:	Macpherson, Andrew J., Hunziker, Lukas, McCoy, Kathy, Lamarre, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Antibody production B-Lymphocytes - physiology bacteria Bile - immunology Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Humans IgA Immunobiology Immunoglobulin A, Secretory - biosynthesis Immunoglobulin Class Switching Intestinal Diseases - immunology intestinal mucosa Intestinal Mucosa - immunology Intestines - microbiology Milk - immunology Rotavirus Infections - immunology viruses
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Beschreibung
Zusammenfassung:	IgA is the most abundant immunoglobulin produced in mammals; most is secreted as a dimer across mucous membranes. This review discusses the different mechanisms of induction of IgA, and its role in protecting mucosal surfaces against pathogenic and non-pathogenic microorganisms.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/S1286-4579(01)01460-5