Efficacy of Re-188-labelled sulphur colloid on prolongation of survival time in melanoma-bearing animals

In this study, the effectiveness of a 188Re labeled sulfur colloid with two particle size ranges was used to evaluate the effectiveness of this agent on melanoma tumors in mice in terms of animal lifespan. Two separate group of animals were used for investigating biodistribution and survival time. A...

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Veröffentlicht in:Nuclear medicine and biology 2001-10, Vol.28 (7), p.835-844
Hauptverfasser: CHEN, F. D, HSIEH, B. T, WANG, H. E, OU, Y. H, YANG, W. K, WHANG-PENG, J, LIU, R. S, KNAPP, F. F, TING, G, YEN, S. H
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Sprache:eng
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Zusammenfassung:In this study, the effectiveness of a 188Re labeled sulfur colloid with two particle size ranges was used to evaluate the effectiveness of this agent on melanoma tumors in mice in terms of animal lifespan. Two separate group of animals were used for investigating biodistribution and survival time. A total of 188 B16F10-melanoma-bearing BDF(1) mice were injected intraperitoneally with 3.7 MBq (0.1mCi)/2mL of radiolabeled sulfur colloid ten days after intraperitoneal inoculation of 5x10(5) B16F10 melanoma cells/2ml. For group 1, 30 mice were sacrificed at 1, 4, 24, 48 and 72 hours for biodistribution studies. In group 2, 158 mice were divided into 9 groups (n=16 approximately 18/groups)each receiving respectively tumor alone, tumor with normal saline, cold colloid or hot colloid with 16, 23, 31, 46, 62, or 124 MBq activity. Each of these colloid groups was further divided into two groups, one receiving smaller particle sizes (
ISSN:0969-8051
1872-9614
DOI:10.1016/S0969-8051(01)00244-X