Serial analysis of MLL‐AF4 chimeric message through successful bone marrow transplantation in a patient with t(4;11)‐positive infant‐ALL

A 28‐month‐old girl with acute lymphoblastic leukemia (ALL) showing a t(4;11)(q21;q23) karyotype successfully underwent allogeneic bone marrow transplantation (BMT) at relapse. The chimeric MLL‐AF4 message on her bone marrow (BM) specimens, examined by reverse transcriptase‐polymerase chain reaction...

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Veröffentlicht in:	American journal of hematology 2000-07, Vol.64 (3), p.203-205
Hauptverfasser:	Tabata, Yasuhiro, Hibi, Shigeyoshi, Maruyama‐Tabata, Hiroko, Tsunamoto, Kentaro, Todo, Shinjiro, Sawada, Tadashi, Okamura, Takayuki, Kawa‐Ha, Keisei, Imashuku, Shinsaku
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lymphoblastic leukemia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers, Tumor - analysis bone marrow transplantation Bone Marrow Transplantation - physiology Bone marrow, stem cells transplantation. Graft versus host reaction Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 4 Female Hematologic and hematopoietic diseases Humans Infant Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences minimal residual disease MLL‐AF4 Myeloid-Lymphoid Leukemia Protein Neoplasm Proteins - genetics Oncogene Proteins, Fusion - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Recombinant Fusion Proteins - genetics t(4 11) Transfusions. Complications. Transfusion reactions. Cell and gene therapy Translocation, Genetic
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Zusammenfassung:	A 28‐month‐old girl with acute lymphoblastic leukemia (ALL) showing a t(4;11)(q21;q23) karyotype successfully underwent allogeneic bone marrow transplantation (BMT) at relapse. The chimeric MLL‐AF4 message on her bone marrow (BM) specimens, examined by reverse transcriptase‐polymerase chain reaction, was detectable at diagnosis, relapse, and just before BMT but became undetectable following BMT. She has since maintained complete remission. This observation suggests that detection of the chimeric message in BM may be useful to predict clinical outcome in patients with t(4;11) ALL. Am. J. Hematol. 64:203–205, 2000. © 2000 Wiley‐Liss, Inc.
ISSN:	0361-8609 1096-8652
DOI:	10.1002/1096-8652(200007)64:3<203::AID-AJH11>3.0.CO;2-5