Cytotoxic Lavandulyl Flavanones from Sophora flavescens

Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (-)-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-05, Vol.63 (5), p.680-681
Hauptverfasser:	KANG, Tai-Hyun, JEONG, Sei-Joon, KO, Won-Gil, KIM, Na-Young, LEE, Byung-Hoon, INAGAKI, Masanori, MIYAMOTO, Tomofumi, HIGUCHI, Ryuichi, KIM, Youn-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology China Cisplatin - pharmacology Drug Screening Assays, Antitumor Fabaceae - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology HL-60 Cells Humans Magnetic Resonance Spectroscopy Plant Roots - chemistry Plants, Medicinal - chemistry Tumor Cells, Cultured
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Zusammenfassung:	Two new lavandulylated flavanones, (2S)-2'-methoxykurarinone (1) and (-)-kurarinone (2), were isolated from the root of Sophora flavescens, together with two known lavandulyl flavanones, sophoraflavanone G (3) and leachianone A (4), and two known isoflavonoids, formononetin and l-maakiain. The structures of 1 and 2 were determined on the basis of optical rotation and spectral evidence and by comparison with known compounds. Compounds 1-4 exhibited cytotoxic activity against human myeloid leukemia HL-60 cells.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np990567x